Catherine B. Lawrence

Dual MMP-9/12 Inhibition with AZD1236 Confers Neurovascular Protection and Reduces Post-Stroke Pain in Experimental Stroke Models.

This study evaluates AZD1236, a dual MMP-9/-12 inhibitor, showing reduced infarct/hematoma volumes, improved neurological outcomes, and pain mitigation in stroke models.

In vivo cellular localisation and nanoscale organisation of NLRP3 inflammasomes

This study uses reporter mice to visualise NLRP3 inflammasomes in vivo, revealing their localisation, organisation, and cellular sources.

Vascular dilation modulates brain haematoma expansion in larval zebrafish

This study shows that vascular dilation reduces haematoma size in zebrafish ICH models, suggesting haemodynamic regulation influences haemorrhage progression.

Cell volume tunes macrophage innate inflammatory responses through promoting type I interferon signalling.

This study shows that cell volume changes in macrophages enhance type I interferon signaling and inflammation through a DNA- and STING-dependent mechanism.

Inflammatory responses following CRISPR modification of the nuclear localisation sequence in endogenous interleukin-1α

This study disrupts the nuclear localisation sequence of endogenous IL-1α in mice and examines its effects on inflammatory responses, finding no significant changes in LPS-induced transcriptional signatures or IL-1 release.

Cerebral ischaemic stroke results in altered mucosal IgA responses and host-commensal microbiota interactions.

This study shows that cerebral ischaemic stroke alters mucosal IgA responses and host-commensal microbiota interactions, leading to changes in intestinal microbiota composition.

25-hydroxycholesterol promotes brain endothelial dysfunction by remodelling cholesterol metabolism

The paper shows that 25-hydroxycholesterol disrupts brain endothelial function by altering cholesterol metabolism, linking viral infection to brain vessel dysfunction in intracerebral haemorrhage.

Genomic and biological panoramas of non-muscle actinopathies

The paper analyzes clinical and mechanistic data from individuals with ACTB/ACTG1 variants to identify distinct disease phenotypes and molecular mechanisms of non-muscle actinopathies.

Brazilin is a Natural Product Inhibitor of the NLRP3 Inflammasome

This study identifies brazilin as a natural product inhibitor of the NLRP3 inflammasome, effective in multiple models and suggesting its potential as a therapeutic scaffold.

Re-Evaluating One-step Generation of Mice Carrying Conditional Alleles by CRISPR-Cas9-Mediated Genome Editing Technology

The paper re-evaluates the efficiency of a CRISPR-Cas9 method for generating conditional knockout alleles in mice, finding very low success rates and high rates of undesired alleles.