Jack Green

This study uses reporter mice to visualise NLRP3 inflammasomes in vivo, revealing their localisation, organisation, and cellular sources.

This study shows that cell volume changes in macrophages enhance type I interferon signaling and inflammation through a DNA- and STING-dependent mechanism.

This study disrupts the nuclear localisation sequence of endogenous IL-1α in mice and examines its effects on inflammatory responses, finding no significant changes in LPS-induced transcriptional signatures or IL-1 release.

This study investigates how lysosome positioning affects NLRP3 inflammasome activation in HeLa and macrophage cells, finding that peripheral lysosome positioning enhances inflammasome activation.

This study shows the NLRP3 inflammasome is crucial for IL-18 production in a murine model of MAS but not for other disease features.

This study identifies brazilin as a natural product inhibitor of the NLRP3 inflammasome, effective in multiple models and suggesting its potential as a therapeutic scaffold.