Author

Sally Freeman

Manchester Academic Health Science CentreORCID 0000-0002-3831-9151Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 2 Organism:Drosophila· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Approach:statistical model· 1

Frequent Co-Authors

Andrew J. TrevelyaniD· 1 shared Catherine B. LawrenceiD· 1 shared Christopher HoyleiD· 1 shared Connie Mackenzie‐Gray ScottiD· 1 shared David BroughiD· 1 shared Emily McMahon· 1 shared Emma V. JonesiD· 1 shared Eve CorrieiD· 1 shared

Activity by Year

2022-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperNeuroscience

Andrew J. TrevelyanORCID

Mutual co-authors in cluster

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2 papers

Recent·Most cited

Brazilin is a Natural Product Inhibitor of the NLRP3 Inflammasome

Emily McMahon, Sherihan El‐Sayed, Jack Green, Christopher Hoyle, Lorna M. FitzPatrick, Emma V. Jones, Eve Corrie, Rebecca L. Kelly, Mairi Challinor, Sally Freeman, Richard A. Bryce, Catherine B. Lawrence, David Brough, Paul R. Kasher

This study identifies brazilin as a natural product inhibitor of the NLRP3 inflammasome, effective in multiple models and suggesting its potential as a therapeutic scaffold.

iScience · Jan 21, 2024Peer-reviewedMolecular Biology

Targeting neuronal homeostasis to prevent seizures

Fred Mulroe, Wei‐Hsiang Lin, Connie Mackenzie‐Gray Scott, Najat Aourz, Yuen Ngan Fan, Graham Coutts, R. Ryley Parrish, Ilse Julia Smolders, Andrew J. Trevelyan, Robert C. Wykes, Stuart McRae Allan, Sally Freeman, Richard Baines

This study identifies a novel anticonvulsant compound that targets neuronal homeostasis by increasing Pumilio expression, showing efficacy in Drosophila and mouse seizure models.

bioRxiv · Mar 7, 2022 · PreprintNeuroscience