Mechanism of ATXN8OS CTA/CTG repeat-associated non-AUG translation revealed by approaches ranging from cell-free translation to live-cell imaging.
Soyoka Sakamoto, Hayato Ito, Mayuka Hasumi, Tatsuya Morisaki, Makito Hirano, Yoshitaka Nagai, Timothy J. Stasevich, HIDEKI TAGUCHI
This study identifies the mechanism of ATXN8OS CTA/CTG repeat-associated non-AUG translation through cell-free systems and live-cell imaging, revealing frameshifting and stress response involvement.
bioRxiv · Jan 27, 2026 · PreprintBiochemistry