Yoshitaka Nagai

This paper develops a preclinical treatment for PTSD using a peptide that blocks CPEB3 amyloid formation, reducing traumatic memory consolidation and PTSD-like symptoms in mice.

This study identifies the mechanism of ATXN8OS CTA/CTG repeat-associated non-AUG translation through cell-free systems and live-cell imaging, revealing frameshifting and stress response involvement.

The paper identifies eIF1A and eIF5B as repressors of C9orf72-mediated RAN translation by showing their omission enhances RAN translation in all reading frames.

This paper describes a second-generation transgenic marmoset model of SCA3 that replicates motor impairments and neuropathology, offering a platform for studying disease mechanisms and therapies.

This study shows FUS suppresses RAN translation by modulating G-quadruplex structure of GGGGCC repeat RNA, reducing neurodegeneration in C9-ALS/FTD model flies.

The paper compares the amyloid-like assembly mechanisms of CPEB prion-like domains from Aplysia and Drosophila, showing divergent pathways leading to a common fold.