Author

Hayato Ito

Institute of Science TokyoORCID 0000-0002-1437-5853Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Assay:multiome· 1 Assay:proteomics· 1

Frequent Co-Authors

HIDEKI TAGUCHIiD· 3 shared Yoshitaka NagaiiD· 3 shared Mayuka Hasumi· 2 shared Soyoka Sakamoto· 2 shared Yuzo FujinoiD· 2 shared Akihide KoyamaiD· 1 shared Akira IshiguroiD· 1 shared Asako Murata· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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3 shared papersBiochemistry

HIDEKI TAGUCHIORCID

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3 papers

Recent·Most cited

BiochemistrybioRxivPreprintJan 27, 2026

Mechanism of ATXN8OS CTA/CTG repeat-associated non-AUG translation revealed by approaches ranging from cell-free translation to live-cell imaging.

Soyoka Sakamoto, Hayato Ito, Mayuka Hasumi…·HIDEKI TAGUCHI

This study identifies the mechanism of ATXN8OS CTA/CTG repeat-associated non-AUG translation through cell-free systems and live-cell imaging, revealing frameshifting and stress response involvement.

DOI 10.64898/2026.01.25.700793

humanmultiome

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BiochemistryNucleic Acids ResearchPeer-reviewedSep 23, 2025

Canonical translation factors eIF1A and eIF5B modulate the initiation step of repeat-associated non-AUG translation.

Hayato Ito, Kodai Machida, Yuzo Fujino…·Hideki Taguchi

The paper identifies eIF1A and eIF5B as repressors of C9orf72-mediated RAN translation by showing their omission enhances RAN translation in all reading frames.

7 citations

humanproteomics

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NeuroscienceeLifePeer-reviewedFeb 13, 2023

FUS regulates RAN translation through modulating the G-quadruplex structure of GGGGCC repeat RNA in C9orf72-linked ALS/FTD

Yuzo Fujino, Morio Ueyama, Taro Ishiguro…·Yoshitaka Nagai

This study shows FUS suppresses RAN translation by modulating G-quadruplex structure of GGGGCC repeat RNA, reducing neurodegeneration in C9-ALS/FTD model flies.

20 citations

experimental assay

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