STAT1-Mediated Regulation of IL-17A/CEBPB/NF-κB Axisin HIV-1 Infected Human Cerebral Organoids RevealsTherapeutic Targets for Neuroprotection
Karthick Chennakesavan, Malaroviyam Samikkannu, Shreyan Gupta, Tayo Israel Olasunkanmi, Arpan Acharya, James J. Cai, Siddappa N. Byrareddy, Thangavel Samikkannu
The paper identifies IL-17A, STAT1, CEBPB, and cGAS-STING as key drivers of HIV-associated neuroinflammation using HIV-infected cerebral organoids and validates findings in a primate model.
bioRxiv · Jan 2, 2026 · PreprintNeuroscience