Siddappa N. Byrareddy

Intranasal Delivery of HIV/SIV Antigens with NE/AS01B Adjuvants Enhances Cellular Immunity and Reduces Viral Loads in SHIV-Challenged Macaques

STAT1-Mediated Regulation of IL-17A/CEBPB/NF-κB Axisin HIV-1 Infected Human Cerebral Organoids RevealsTherapeutic Targets for Neuroprotection

The paper identifies IL-17A, STAT1, CEBPB, and cGAS-STING as key drivers of HIV-associated neuroinflammation using HIV-infected cerebral organoids and validates findings in a primate model.

Neurovirulent and non-neurovirulent strains of HIV-1 and their Tat proteins induce differential cytokine-chemokine profiles

The paper compares cytokine-chemokine profiles induced by neurovirulent and non-neurovirulent HIV-1 strains and their Tat proteins, showing differential inflammatory responses.

TISSUE-SPECIFIC METABOLOMIC REPROGRAMMING DETERMINES THE DISEASE PATHOPHYSIOLOGY OF SARS-COV-2 VARIANTS IN HAMSTER MODEL

The paper investigates tissue-specific metabolic reprogramming and gut dysbiosis in hamsters infected with SARS-CoV-2 variants, revealing differences in viremia, metabolic responses, and microbiota composition between delta and omicron variants.

Morphine Suppresses Peripheral Responses and Transforms Brain Myeloid Gene Expression to Favor Neuropathogenesis in SIV Infection

This study shows morphine suppresses immune responses and alters brain myeloid gene expression in SIV-infected macaques, promoting neuropathogenesis.

Discovery and in-vitro evaluation of potent SARS-CoV-2 entry inhibitors

The paper identifies and evaluates two potent SARS-CoV-2 entry inhibitors through computational screening and in vitro testing, showing synergy with remdesivir.

Factors Associated with Emerging and Re-emerging of SARS-CoV-2 Variants

The paper identifies factors contributing to the higher infectivity of SARS-CoV-2 variants using bioinformatics and structural analysis.

Chronic morphine administration differentially modulates viral reservoirs in SIVmac251 infected rhesus macaque model

This study shows that chronic morphine administration reduces SIV reservoirs in peripheral blood and lymph nodes but increases them in CNS microglia/macrophages in SIV-infected rhesus macaques.