Author

Malavika Srikanth

Columbia University Irving Medical Center

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Neuroscience· 2 Pathology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 2 Organism:mouse· 2 Assay:proteomics· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Organism:human· 1

Frequent Co-Authors

Natura MyekuiD· 3 shared Shan JiangiD· 3 shared Avery M. RunyaniD· 2 shared Eric J. Sydney· 2 shared Helen Y. Figueroa· 2 shared Mu YangiD· 2 shared Rossana Serpe· 2 shared Daniella LormaniD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersNeuroscience

Natura MyekuORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Immunoproteasome Deficiency Impairs Microglial Clearance and Worsens Tau and Amyloid Pathology

Malavika Srikanth, Shan Jiang, Steven M. Wellman, Shrita Sarkar, Daniella Lorman, Timothy Lantin, Avery M. Runyan, Mayank Kumar, Eric J. Sydney, Helen Y. Figueroa, Mu Yang, Qi Wang, Natura Myeku

This study shows that immunoproteasome deficiency in mice worsens tau and amyloid pathology by impairing microglial clearance.

bioRxiv · Jul 20, 2026 · PreprintNeuroscience

Early Proteasome Gene Downregulation And Impaired Proteasomes Function Underlie Proteostasis Failure In Alzheimer's Disease

Shan Jiang, Malavika Srikanth, Rossana Serpe, Shadi Yavari, Palavi Gaur, Galen Andrew Collins, Rajesh Kumar Soni, Vilas Menon, Natura Myeku

This study identifies early proteasome dysfunction and transcriptional downregulation in Alzheimer's disease, contributing to proteostasis failure and neurodegeneration.

bioRxiv · Jan 21, 2025 · PreprintPathology

5-HT4 receptor agonists treatment reduces tau pathology and behavioral deficit in the PS19 mouse model of tauopathy

Shan Jiang, Eric J. Sydney, Avery M. Runyan, Rossana Serpe, Malavika Srikanth, Helen Y. Figueroa, Mu Yang, Natura Myeku

This study shows that 5-HT4 receptor agonists reduce tau pathology and improve cognitive function in PS19 mice with tauopathy.

Frontiers in Cellular Neuroscience · Apr 4, 2024Peer-reviewedNeuroscience