Shan Jiang

This study shows that immunoproteasome deficiency in mice worsens tau and amyloid pathology by impairing microglial clearance.

This study shows that pathological tau expression in the anterodorsal thalamic nucleus disrupts head direction signaling, leading to spatial disorientation in mice.

The paper identifies distinct subtypes of head direction cells in the mouse anterodorsal thalamus based on their response profiles and connectivity patterns.

This study identifies early proteasome dysfunction and transcriptional downregulation in Alzheimer's disease, contributing to proteostasis failure and neurodegeneration.

This study identifies PVHCRH neurons as regulators of sevoflurane anesthesia and post-anesthesia stress responses through chemogenetic and optogenetic manipulations.

This study shows that 5-HT4 receptor agonists reduce tau pathology and improve cognitive function in PS19 mice with tauopathy.