Qi Wang

This study shows that long-term locus coeruleus stimulation worsens memory, synaptic plasticity, and Tau pathology in PS19 mice.

This study shows that immunoproteasome deficiency in mice worsens tau and amyloid pathology by impairing microglial clearance.

The paper examines how behavioral states influence norepinephrine dynamics in somatosensory and prefrontal cortices during tactile detection tasks, linking pupil size and NE signaling to task performance.

This study investigates how the locus coeruleus-norepinephrine system influences the coupling between pupil-linked arousal and cortical state using optogenetics, EEG, and machine learning.

The paper examines alpha modulation of spiking activity in multiple brain regions of mice during a tactile detection task, finding differences in modulation across regions and cell types, and a correlation with task performance.

This study shows that modulating somatostatin-expressing interneurons in the basolateral amygdala affects different types of neuropathic pain in mice.

This study investigates how phase synchrony between prefrontal noradrenergic and cholinergic signals relates to inhibitory control in mice.

This study maps brain-wide, cell-type-specific gene expression changes in mice following LC-NE system activation or inhibition using single-nucleus RNA sequencing.

This study analyzes LC neuron firing patterns across species and biological factors, revealing diverse activity patterns and subregions enriched for specific factors and disease models.

This study uses optogenetics and machine learning to show that LC stimulation in mice alters cortical states and pupillary responses, linking LC activity to arousal regulation.

This study shows that rats adjust their decision-making criteria based on stimulus probability and pupil-linked arousal to maximize rewards in tactile discrimination tasks.