Natura Myeku

This study shows that immunoproteasome deficiency in mice worsens tau and amyloid pathology by impairing microglial clearance.

This study identifies early proteasome dysfunction and transcriptional downregulation in Alzheimer's disease, contributing to proteostasis failure and neurodegeneration.

This study shows that 5-HT4 receptor agonists reduce tau pathology and improve cognitive function in PS19 mice with tauopathy.

This study shows that targeting GPCRs to enhance synaptic proteasome activity reduces tau accumulation and cognitive decline in a mouse model of Alzheimer's disease.