Endothelial Cu Uptake Transporter CTR1 Senses Disturbed Flow to Promote Atherosclerosis through Cuproptosis
Sudhahar Varadarajan, Zhen Xiao, Archita Das, Dipankar Ash, Shikha Yadav, Carson D. Matier, Aidan T. Pezacki, Barun Chatterjee, Olga A. Antipova, Stefan Vogt, Malgorzata McMenamin, Stephanie Kelley, Gábor Csányi, Jaekwon Lee, Hanjoong Jo, , Tohru Fukai
This study shows that endothelial CTR1 senses disturbed flow by increasing mitochondrial copper, leading to cuproptosis and atherosclerosis, and identifies a therapeutic target.
bioRxiv · Jan 27, 2025 · PreprintCell Biology