Author

Sudhahar Varadarajan

Augusta UniversityORCID 0000-0002-9675-0097Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:mouse· 5 Approach:experimental assay· 4 Assay:bulk RNA-seq· 2 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Research Focus:host-pathogen & immune response· 2 Assay:ATAC-seq· 1 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

Masuko Ushio‐FukaiiD· 5 shared Archita DasiD· 4 shared Tohru FukaiiD· 4 shared Dipankar AshiD· 3 shared Mai YamamotoiD· 2 shared Md. Selim HossainiD· 2 shared Ruth B. CaldwelliD· 2 shared Sheela NagarkotiiD· 2 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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5 shared papersCell Biology

Masuko Ushio‐FukaiORCID

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5 papers

Recent·Most cited

Myeloid DRP1 Sulfenylation Drives Reparative Macrophage Polarization and Neovascularization in Ischemic Muscle

Shikha Yadav, Kamarajan Rajagopal, Sudhahar Varadarajan, Sheela Nagarkoti, Archita Das, Stephanie Kelley. Spears, Rajalakshmi Veeranan‐Karmegam, Tohru Fukai, Masuko Ushio‐Fukai

This study identifies DRP1 sulfenylation as a redox-dependent mechanism driving reparative macrophage polarization and neovascularization in ischemic muscle.

Antioxidants · Jun 19, 2026Peer-reviewedCell Biology

Novel Role of Copper Transporter CTR1 and Therapeutic Potential of Copper Chelators in Retinal Ischemia-Reperfusion Injury

Mai Yamamoto, Dipankar Ash, Sudhahar Varadarajan, Syed Adeel H. Zaidi, Modesto Rojas, Zhimin Xu, Stephanie Sinclair Kelley, Ruth B. Caldwell, Tohru Fukai, Masuko Ushio‐Fukai

This study shows that CTR1 contributes to retinal ischemia-reperfusion injury by promoting oxidative stress and inflammation, and that copper chelators like TTM can mitigate these effects.

bioRxiv · May 17, 2025 · PreprintCell Biology

Endothelial Cu Uptake Transporter CTR1 Senses Disturbed Flow to Promote Atherosclerosis through Cuproptosis

Sudhahar Varadarajan, Zhen Xiao, Archita Das, Dipankar Ash, Shikha Yadav, Carson D. Matier, Aidan T. Pezacki, Barun Chatterjee, Olga A. Antipova, Stefan Vogt, Malgorzata McMenamin, Stephanie Kelley, Gábor Csányi, Jaekwon Lee, Hanjoong Jo, , Tohru Fukai

This study shows that endothelial CTR1 senses disturbed flow by increasing mitochondrial copper, leading to cuproptosis and atherosclerosis, and identifies a therapeutic target.

bioRxiv · Jan 27, 2025 · PreprintCell Biology

Altered Copper Transport in Oxidative Stress-Dependent Brain Endothelial Barrier Dysfunction Associated with Alzheimer's Disease

Md. Selim Hossain, Archita Das, Ashiq Mahmood Rafiq, Ferenc Deák, Zsolt A Bagi, Rashelle Outlaw, Sudhahar Varadarajan, Mai Yamamoto, Jack H. Kaplan, Masuko Ushio‐Fukai, Tohru Fukai

This study investigates the role of copper transport proteins in Alzheimer's disease by examining their expression and function in AD mouse models and human brain endothelial cells.

Vascular Pharmacology · Dec 1, 2024Peer-reviewedNeuroscience

Endothelial Drp1 Couples VEGF-induced Redox Signaling with Glycolysis Through Cysteine Oxidation to Drive Angiogenesis

Sheela Nagarkoti, Young-Mee Kim, Archita Das, Dipankar Ash, Eric A. Vitriol, Tracy‐Ann Read, Sudhahar Varadarajan, Md. Selim Hossain, Shikha Yadav, Maggie McMenamin, Kelvin Orji, Maritza Josefina Romero, Rudolf Lucas, D. W. A. Stepp, Eric J. Belin de Chantemele, , Masuko Ushio‐Fukai

Nature Communications · Nov 1, 2024Peer-reviewedCell Biology