Tohru Fukai

This study identifies DRP1 sulfenylation as a redox-dependent mechanism driving reparative macrophage polarization and neovascularization in ischemic muscle.

This study shows that neddylation regulates mitochondrial dynamics and turnover in the adult heart, linking its disruption to cardiomyopathy and heart failure.

This study shows that CTR1 contributes to retinal ischemia-reperfusion injury by promoting oxidative stress and inflammation, and that copper chelators like TTM can mitigate these effects.

This study shows that endothelial CTR1 senses disturbed flow by increasing mitochondrial copper, leading to cuproptosis and atherosclerosis, and identifies a therapeutic target.

This study investigates the role of copper transport proteins in Alzheimer's disease by examining their expression and function in AD mouse models and human brain endothelial cells.