Characterisation and prion transmission study in mice with genetic reduction of sporadic Creutzfeldt-Jakob Disease risk gene Stx6
Emma L. Jones, Elizabeth Hill, Jacqueline M. Linehan, Tamsin Nazari, Adam Caulder, Gemma F. Codner, Marie Hutchison, Matthew Mackenzie, Michael Farmer, Thomas Coysh, Michael Wiggins De Oliveira, Huda Al-Doujaily, Malin K. Sandberg, Emmanuelle A. Viré, Thomas J. Cunningham, , Simon Mead
This study investigates the role of Stx6 in prion disease by creating a mouse model with genetic depletion of Stx6 and finding a modest effect on prion disease incubation periods.
bioRxiv · Jan 10, 2023 · PreprintNeuroscience