Jacqueline M. Linehan

A dividing cell model for stable propagation and curing of bona fide human sporadic Creutzfeldt-Jakob Disease prions

This paper introduces a cell-based system for propagating and quantifying human prion infectivity using CAD5 cells expressing human prion protein, demonstrating its effectiveness and therapeutic potential.

Intracellular Trafficking SNARE Protein, Syntaxin-6, is a Modifier of Prion and Tau Pathogenesis in vivo and in Cellular Models

This study identifies syntaxin-6 as a modifier of prion and tau pathogenesis, showing it affects disease onset but not progression in experimental models.

Induction and characterisation of Abeta and tau pathology in AppNL-F/NL-F mice following inoculation with Alzheimer's disease brain homogenate

This study inoculates AppNL-F/NL-F mice with AD brain homogenates to study A{beta} and tau pathology, finding prion-like propagation and new insights into their interactions.

Characterisation and prion transmission study in mice with genetic reduction of sporadic Creutzfeldt-Jakob Disease risk gene Stx6

This study investigates the role of Stx6 in prion disease by creating a mouse model with genetic depletion of Stx6 and finding a modest effect on prion disease incubation periods.

Single-nuclei transcriptomics of mammalian prion diseases identifies dynamic gene signatures shared between species

This study uses single-nuclei transcriptomics to identify dynamic gene signatures in prion diseases across species.