Author

Marie Hutchison

Mary Lyon Centre at MRC Harwell

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genetics· 2 Molecular Biology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 4 Research Focus:variant calling· 2 Research Focus:benchmarking· 1 Assay:CRISPR screen· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

Adam CaulderiD· 3 shared Gemma F. CodneriD· 3 shared Matthew MackenzieiD· 3 shared Sara E. WellsiD· 3 shared Alasdair J. AllaniD· 2 shared Colin McKerlieiD· 2 shared Jacqueline K. WhiteiD· 2 shared John R. SeavittiD· 2 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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Curved chords = mutual co-authorship

3 shared papersGenetics

Adam CaulderORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Impact of Essential Genes on the Success of Genome Editing Experiments Generating 3,313 New Genetically Engineered Mouse Lines

Hillary Elrick, Kevin A. Peterson, Brandon Willis, Denise Grant Lanza, Elif Fidan Acar, Edward J. Ryder, Lydia Teboul, Petr Kašpárek, Marie‐Christine Birling, David J. Adams, Allan Bradley, Robert E. Braun, Steve D. M. Brown, Adam Caulder, Gemma F. Codner, , Valerie Laurin

The paper analyzes 3,313 genetically engineered mouse lines to identify gene essentiality as the main factor affecting Cas9-based genome editing success.

Scientific Reports · Sep 30, 2024Peer-reviewedGenetics

Application of long-read sequencing for robust identification of correct alleles in genome edited animals

Christopher V. McCabe, Peter D. Price, Gemma F. Codner, Alasdair J. Allan, Adam Caulder, Skevoulla Christou, Jorik Loeffler, Matthew Mackenzie, Elke Malzer, Joffrey Mianné, Krystian J. Nowicki, Edward J. O’Neill, Fran J. Pike, Marie Hutchison, Benoit Petit‐Demoulière, , Lydia Teboul

This study uses long-read sequencing to accurately identify correct alleles in genome-edited animals despite mosaicism and complex edits.

PLoS Genetics · Mar 8, 2024Peer-reviewedMolecular Biology

Characterisation and prion transmission study in mice with genetic reduction of sporadic Creutzfeldt-Jakob Disease risk gene Stx6

Emma L. Jones, Elizabeth Hill, Jacqueline M. Linehan, Tamsin Nazari, Adam Caulder, Gemma F. Codner, Marie Hutchison, Matthew Mackenzie, Michael Farmer, Thomas Coysh, Michael Wiggins De Oliveira, Huda Al-Doujaily, Malin K. Sandberg, Emmanuelle A. Viré, Thomas J. Cunningham, , Simon Mead

This study investigates the role of Stx6 in prion disease by creating a mouse model with genetic depletion of Stx6 and finding a modest effect on prion disease incubation periods.

bioRxiv · Jan 10, 2023 · PreprintNeuroscience

The occurrence of tarsal injuries in male mice of C57BL/6N substrains in multiple international mouse facilities

Eleanor Herbert, Michelle E. Stewart, Marie Hutchison, Ann Marie Flenniken, Dawei Qu, Lauryl M. J. Nutter, Colin McKerlie, Liane Hobson, Brenda L. Kick, Bonnie L. Lyons, Jean-Paul Wiegand, Rosalinda A. Doty, Juan Antonio Aguilar‐Pimentel, Martin Hrabě de Angelis, Mary E. Dickinson, , Sara E. Wells

The paper reports on the occurrence of tarsal injuries in male C57BL/6N mice across multiple international facilities, describing clinical signs and findings from radiographic and histological analyses.

PLoS ONE · Jun 15, 2020Peer-reviewedGenetics