N-acetyl-L-leucine (Levacetylleucine) normalizes Transcription Factor EB (TFEB) activity by stereospecific bidirectional modulation
Lianne C. Davis, Rebecca Braine, Grant C. Churchill, Mallory Factor, Taylor Fields, Marc C. Patterson, Frances M. Platt, Michael Leo Strupp, Antony Galione
This paper demonstrates that levacetylleucine modulates TFEB activity in a bidirectional manner, normalizing lysosomal function in both wild-type and NPC1 knockout cells.
bioRxiv · Dec 2, 2025 · PreprintPharmacology & Toxicology