Stereospecific rapid activation of Transcription Factor EB (TFEB) by Levacetylleucine (NALL)
Lianne C. Davis, Rebecca Brain, Grant C. Churchill, Mallory Factor, Taylor Fields, Frances M. Platt, Marc C. Patterson, Michael Leo Strupp, Antony Galione
This paper shows that NALL activates TFEB, enhancing lysosomal and autophagic function, which may explain its therapeutic effects in neurodegenerative diseases.
bioRxiv · Jun 6, 2025 · PreprintPharmacology & Toxicology