Combinatorial inhibition of LSD1 and Menin induces therapeutic differentiation in AML
María F. Carrera Rodríguez, Joshua Rico, Manaswini Vijayaraghavan, Fangxue Yan, Austin King, Ricardo Petroni, Nicolae Adrian Leu, Haley Goodrow, Kathrin Maria Bernt, Gerald M. McGeehan, Mario Andres Blanco
This paper identifies dual inhibition of LSD1 and Menin as a promising therapeutic strategy for non-APL AML by inducing terminal differentiation through distinct molecular mechanisms.
bioRxiv · Nov 9, 2025 · PreprintCancer Biology