Author

Ricardo Petroni

University of Pennsylvania

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 2 Approach:experimental assay· 2 Organism:mouse· 2 Assay:ATAC-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Joshua RicoiD· 2 shared María F. Carrera RodrígueziD· 2 shared Mario Andres BlancoiD· 2 shared Nicolae Adrian Leu· 2 shared Alexander MeissneriD· 1 shared Ashwini JambhekariD· 1 shared Austin King· 1 shared Christopher J. LengneriD· 1 shared

Activity by Year

2021-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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2 shared papersCancer Biology

Joshua RicoORCID

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Author profile →

3 papers

Recent·Most cited

APC coordinates GSK3 phosphorylation of SETD8 to suppress colorectal cancer

Zvi Cramer, Keara Monaghan, Ricardo Petroni, Xin Wang, Stephanie Adams-Tzivelekidis, Kayla Durning, Melissa S. Kim, Yuhua Tian, Nicolette M. Johnson, María F. Carrera Rodríguez, Xiaoyuan Gao, Nicolae Adrian Leu, Simone Sidoli, Ning O. Li, M. Andres Blanco, Christopher J. Lengner

This study identifies SETD8 as a target of APC-coordinated GSK3 phosphorylation in colorectal cancer, showing that phosphorylation suppresses SETD8's oncogenic activity.

Cell Reports · Mar 1, 2026Peer-reviewedCancer Biology

Combinatorial inhibition of LSD1 and Menin induces therapeutic differentiation in AML

María F. Carrera Rodríguez, Joshua Rico, Manaswini Vijayaraghavan, Fangxue Yan, Austin King, Ricardo Petroni, Nicolae Adrian Leu, Haley Goodrow, Kathrin Maria Bernt, Gerald M. McGeehan, Mario Andres Blanco

This paper identifies dual inhibition of LSD1 and Menin as a promising therapeutic strategy for non-APL AML by inducing terminal differentiation through distinct molecular mechanisms.

bioRxiv · Nov 9, 2025 · PreprintCancer Biology

Chromatin state barriers enforce an irreversible mammalian cell fate decision

Mario Andres Blanco, David B. Sykes, Lei Gu, Mengjun Wu, Ricardo Petroni, Rahul Karnik, Mathias J. Wawer, Joshua Rico, Haitao Li, William D. Jacobus, Ashwini Jambhekar, Sihem Cheloufi, Alexander Meissner, Konrad Hochedlinger, David T. Scadden, Yang Shi

The paper identifies a point of irreversible commitment in granulocytic differentiation and shows how chromatin state dynamics and transcription factor feedback loops influence this decision.

Cell Reports · Nov 1, 2021Peer-reviewedMolecular Biology