Mario Andres Blanco

This paper identifies dual inhibition of LSD1 and Menin as a promising therapeutic strategy for non-APL AML by inducing terminal differentiation through distinct molecular mechanisms.

This study identifies that APC loss in colorectal cancer drives a β-CATENIN-independent fetal intestinal transcriptional program through YAP activation, leading to bistable stem cell states and enhanced tumorigenesis.

This study uses CRISPR screening to identify genes critical for human primordial germ cell-like cell development, finding TCL1A regulates AKT-mTOR signaling and protein synthesis.

The paper identifies a point of irreversible commitment in granulocytic differentiation and shows how chromatin state dynamics and transcription factor feedback loops influence this decision.

This study shows that CAF-1 maintains myeloid lineage identity by regulating chromatin accessibility and transcription factor control during differentiation.