Kathrin Maria Bernt

Combinatorial inhibition of LSD1 and Menin induces therapeutic differentiation in AML

This paper identifies dual inhibition of LSD1 and Menin as a promising therapeutic strategy for non-APL AML by inducing terminal differentiation through distinct molecular mechanisms.

Beckwith-Wiedemann syndrome multiomic analysis of hepatoblastoma uncovers unique tumor heterogeneity and cellular landscapes, including transition cells leading to tumor formation

This study uses multiomic analysis to identify WNT pathway enrichment and transition cells in BWS hepatoblastoma, revealing unique tumor heterogeneity and potential targets for intervention.

Single-nucleus multiomic analysis of Beckwith-Wiedemann syndrome liver reveals PPARA signaling enrichment and metabolic dysfunction

This study uses single-nucleus multiomic analysis to reveal PPARA signaling enrichment and metabolic dysfunction in BWS liver.