Mansi Gupta

Fine-tuning of Fgf8 morphogen gradient by heparan sulfate proteoglycans in the extracellular matrix

This paper shows that Heparan Sulfate Proteoglycans (HSPGs) in the extracellular matrix bind Fgf8, altering its diffusion and signaling, and contribute to forming the Fgf8 morphogen gradient.

Real-time monitoring of endogenous Fgf8a gradient attests to its role as a morphogen during zebrafish gastrulation

The paper monitors the endogenous Fgf8a gradient in zebrafish gastrulation and confirms its role as a morphogen by showing its graded distribution and signaling effects.