Petra Schwille

The paper introduces PUREdrop, an automated microfluidic platform for screening designed proteins with emergent functions, demonstrating its use on FtsZ variants and modulators.

The paper demonstrates DNA condensate-based organelles that enable spatially regulated gene expression and protein targeting in synthetic cells, showing higher protein yield compared to standard PURE expression.

The paper shows that transcription in confined membrane-bound systems causes RNA phase separation, which is counteracted by translation factors.

This paper shows that Heparan Sulfate Proteoglycans (HSPGs) in the extracellular matrix bind Fgf8, altering its diffusion and signaling, and contribute to forming the Fgf8 morphogen gradient.

This study uses an in vitro model to show how membrane phase separation and bacterial division protein dynamics are interdependent during cell division.

This study demonstrates the self-organized spatial targeting of contractile actomyosin rings in GUVs using the MinDE system, leading to membrane deformation and symmetry breaking.

This study challenges the interpretation of Paleo- and Mesoproterozoic microfossils as fungi by showing bacteria can form protoplasts resembling fungal morphology under similar environmental conditions.

This study combines in silico, in vitro, and in vivo screening to design and validate an ML-generated protein with emergent self-organizing function in E. coli.

The paper introduces a cell-free system for synthesizing prenylated proteins, enabling their production and functional assessment near biomimetic membranes.

This study reconstitutes contractile actomyosin rings in vesicles to study mechanical transformation and deformation mechanisms.

This study identifies three archaeal ESCRT-based cell division mechanisms and suggests an evolutionary link between archaea and eukaryotes through ESCRT similarity.

This study uses microfluidic traps to deform GUVs into non-spherical shapes and observes how FtsZ organization changes in response to membrane geometry.

This study shows that directional actomyosin flows emerge from asymmetric cluster vibrations and spherical confinement in reconstituted actomyosin cortices.

This study investigates how actin cortex remodeling affects lipid domain organization by using reconstituted actin cortices and phase-separated lipid membranes.