Developmental BiologyBiophysical JournalPeer-reviewed
Fine-tuning of Fgf8 morphogen gradient by heparan sulfate proteoglycans in the extracellular matrix
Mansi Gupta, Thomas Kurth, Fabian Heinemann…·Michael Brand
This paper shows that Heparan Sulfate Proteoglycans (HSPGs) in the extracellular matrix bind Fgf8, altering its diffusion and signaling, and contribute to forming the Fgf8 morphogen gradient.
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