A post-transcriptional regulatory checkpoint controls the response of tumor-infiltrating cytotoxic CD4+ T cells to immunotherapy
Maria Vila de Mucha, Julia Hlond, Cristóbal Costoya, Ching‐In Lau, Anna Śledzińska, Imran Uddin, Mariela Navarrete, Mansi Shah, Gerasimos Mastrokalos, Despoina Karagianni, Sarah E. Bell, Callum Baird Nattress, Gordon Beattie, Christopher J. Tape, Martin Turner, , Richard G. Jenner
The paper identifies a post-transcriptional regulatory checkpoint, ZFP36/ZFP36L1, that controls CD4+ T cell cytotoxicity and response to immunotherapy.
bioRxiv · Sep 9, 2025 · PreprintImmunology