Martin Turner

Expression and role of the RNA-binding protein, ZFP36L1, in mouse T follicular helper cell differentiation and function

This study investigates ZFP36L1's role in Tfh cell differentiation and function, finding that its deletion does not impair GC response or affinity maturation.

T cell receptor-ligand affinity quantitatively tunes transcriptome remodelling in vivo, inversely regulating cell division and interferon response

This study shows that TCR-ligand affinity quantitatively modulates transcriptome remodelling in vivo, affecting cell division and interferon response.

RNA-binding proteins control the G2-M checkpoint of the germinal centre B cell

This study identifies ZFP36L1 and ZFP36L2 as RNA-binding proteins that regulate the G2-M checkpoint in GC B cells to prevent replication stress and maintain genome stability.

Differential regulation of TCR-induced ZFP36 and ZFP36L1 expression by cyclosporin A in CD8+ T cells

This study examines how cyclosporin A differentially affects ZFP36 and ZFP36L1 expression in CD8+ T cells by modulating calcineurin signaling.

A post-transcriptional regulatory checkpoint controls the response of tumor-infiltrating cytotoxic CD4+ T cells to immunotherapy

The paper identifies a post-transcriptional regulatory checkpoint, ZFP36/ZFP36L1, that controls CD4+ T cell cytotoxicity and response to immunotherapy.

Regulation of IFNgamma production by ZFP36L2 in T cells is context-dependent

This study shows ZFP36L2 regulates IFNγ production in T cells differently depending on activation context and time, by destabilizing Ifng mRNA in an AU-rich element-dependent manner.

An improved iCLIP protocol

The paper introduces an improved CLIP protocol (iiCLIP) that produces more specific RNA binding site datasets compared to existing methods.

ORFLine: a bioinformatic pipeline to prioritise small open reading frames identifies candidate secreted small proteins from lymphocytes

ORFLine identifies and characterizes small open reading frames in mouse lymphocytes, revealing novel secreted micropeptides.

Zfp36l1 and Zfp36l2 balances proliferation and differentiation in the developing retina

This study shows that Zfp36l1 and Zfp36l2 regulate retinal development by balancing proliferation and differentiation, with their loss causing reduced proliferation and increased differentiation in the retina.

Alternative translation initiation generates a functionally distinct isoform of the stress-activated kinase MK2

The paper identifies an alternative translation initiation site in MK2 mRNA that generates a long isoform with distinct functional properties compared to the short isoform.