Rethinking ratio-based normalization: A guide towards model-based approaches in heart weight analysis
Manuela A. Oestereicher, Patricia da Silva‐Buttkus, Valérie Gailus‐Durner, Susan Marschall, Helmut Fuchs, Martin Hrabě de Angelis, Elida Schneltzer, Nadine Spielmann
This study evaluates ratio-based normalization in heart weight analysis using mouse data, finding that ratios often misrepresent group differences and advocating for linear models with covariate adjustment.
bioRxiv · Sep 1, 2025 · PreprintPhysiology