Nadine Spielmann

EchoVisuALL automates echocardiography analysis in mice, identifying 37 genes linked to cardiac abnormalities through phenotyping and clustering.

This study evaluates ratio-based normalization in heart weight analysis using mouse data, finding that ratios often misrepresent group differences and advocating for linear models with covariate adjustment.

This study establishes TTE reference ranges for mice, showing anesthesia significantly affects cardiac function, with minimal sex differences and modest age-related changes.

This study compares TRα and TRβ knockout mice with DNA-binding-deficient mutants to show noncanonical TR signaling contributes to physiological functions beyond canonical genomic pathways.

This study shows that thyroid hormone-induced cardiac hypertrophy relies on noncanonical TR action, while heart rate regulation depends on canonical TR action, with TRβ compensating for TR absence.

This study shows TRPS1 maintains luminal progenitors in the mammary gland by repressing SRF/MRTF activity, linking it to mechanotransduction and breast cancer initiation.

The paper introduces a method called soft windowing to improve analysis of high-throughput phenotyping data by reducing false positives and increasing significant results.