Helmut Fuchs

Deep proteome and phosphoproteome of Id4-eGFP-sorted mouse spermatogonial stem and progenitor cells reveal 8,464 proteins, poor RNA-protein concordance, and phosphorylation-driven kinase candidates tested functionally.

This study identifies extensive phosphoproteomic remodeling in mouse sperm during maturation and capacitation, revealing key kinases and their roles in fertility.

This study evaluates ratio-based normalization in heart weight analysis using mouse data, finding that ratios often misrepresent group differences and advocating for linear models with covariate adjustment.

This study integrates proteomic data from 12 vertebrate species to identify a core sperm proteome, revealing conserved molecular pathways and validating novel proteins critical for fertility.

This study establishes TTE reference ranges for mice, showing anesthesia significantly affects cardiac function, with minimal sex differences and modest age-related changes.

The paper investigates liver-pancreas interactions after beta-cell loss in zebrafish, identifying a role for the molybdenum cofactor in beta-cell regeneration and glucose metabolism.

The paper identifies monoallelic DHX9 variants as a cause of neurodevelopmental disorders and Charcot-Marie-Tooth disease, showing genotype-phenotype correlations and cellular dysfunction.

The paper reports the generation of over 5,000 new mouse mutant strains for targeted genes, significantly expanding the available genetic resources for biomedical research.

This study shows that SERF2 deletion changes amyloid fibril structure in Alzheimer's mouse models, suggesting SERF's role in modifying amyloid aggregation.

The paper integrates gene essentiality data from human and mouse screens to classify genes into FUSIL categories, identifying developmental lethal genes associated with rare diseases.

The paper demonstrates the use of bacterial encapsulins in eukaryotic cells to create nanocompartments for localized enzymatic reactions and multiscale molecular imaging.