Martin Hrabě de Angelis

FERDINAND harmonizes and preprocesses IMPC radiographs for AI-ready analysis, improving data efficiency for landmark detection.

Deep proteome and phosphoproteome of Id4-eGFP-sorted mouse spermatogonial stem and progenitor cells reveal 8,464 proteins, poor RNA-protein concordance, and phosphorylation-driven kinase candidates tested functionally.

EchoVisuALL automates echocardiography analysis in mice, identifying 37 genes linked to cardiac abnormalities through phenotyping and clustering.

This study identifies extensive phosphoproteomic remodeling in mouse sperm during maturation and capacitation, revealing key kinases and their roles in fertility.

This study evaluates ratio-based normalization in heart weight analysis using mouse data, finding that ratios often misrepresent group differences and advocating for linear models with covariate adjustment.

This study identifies Paralemmin-3 as a critical protein for maintaining the structural integrity of the lateral wall in auditory hair cells, with its loss causing hearing impairment and structural collapse.

This study integrates proteomic data from 12 vertebrate species to identify a core sperm proteome, revealing conserved molecular pathways and validating novel proteins critical for fertility.

This study establishes TTE reference ranges for mice, showing anesthesia significantly affects cardiac function, with minimal sex differences and modest age-related changes.

This study identifies sex-specific molecular differences in human skeletal muscle and shows that endurance training reduces these differences.

This study identifies the eATP/P2X7R axis as a driver of nanoparticle-induced neutrophil recruitment in the pulmonary microcirculation using intravital microscopy in mice.

The paper investigates liver-pancreas interactions after beta-cell loss in zebrafish, identifying a role for the molybdenum cofactor in beta-cell regeneration and glucose metabolism.

The paper identifies monoallelic DHX9 variants as a cause of neurodevelopmental disorders and Charcot-Marie-Tooth disease, showing genotype-phenotype correlations and cellular dysfunction.

The paper reports the generation of over 5,000 new mouse mutant strains for targeted genes, significantly expanding the available genetic resources for biomedical research.

This study shows that SERF2 deletion changes amyloid fibril structure in Alzheimer's mouse models, suggesting SERF's role in modifying amyloid aggregation.

The paper reports on the occurrence of tarsal injuries in male C57BL/6N mice across multiple international facilities, describing clinical signs and findings from radiographic and histological analyses.

The paper integrates gene essentiality data from human and mouse screens to classify genes into FUSIL categories, identifying developmental lethal genes associated with rare diseases.

The paper introduces a method called soft windowing to improve analysis of high-throughput phenotyping data by reducing false positives and increasing significant results.

The paper develops iTAG-RNA to tag RNA in vivo, identifies hepatocyte-specific responses to dietary challenges, and demonstrates liver-to-adipose RNA transfer.

This study shows that Wt1 deletion in mice leads to altered interneuron composition and locomotion defects.

The paper demonstrates the use of bacterial encapsulins in eukaryotic cells to create nanocompartments for localized enzymatic reactions and multiscale molecular imaging.