Valérie Gailus‐Durner

The functional maturation of mouse spermatozoa is underpinned by global remodeling of the cellular phosphoproteome

This study identifies extensive phosphoproteomic remodeling in mouse sperm during maturation and capacitation, revealing key kinases and their roles in fertility.

Rethinking ratio-based normalization: A guide towards model-based approaches in heart weight analysis

This study evaluates ratio-based normalization in heart weight analysis using mouse data, finding that ratios often misrepresent group differences and advocating for linear models with covariate adjustment.

Towards a Kingdom of Reproductive Life - the Core Sperm Proteome

This study integrates proteomic data from 12 vertebrate species to identify a core sperm proteome, revealing conserved molecular pathways and validating novel proteins critical for fertility.

Establishing Comprehensive Transthoracic Echocardiography Reference Ranges for Mouse Models: Insights into the Impact of Anesthesia, Sex, and Age

This study establishes TTE reference ranges for mice, showing anesthesia significantly affects cardiac function, with minimal sex differences and modest age-related changes.

Monoallelic variation in DHX9, the gene encoding the DExH-box helicase DHX9, underlies neurodevelopment disorders and Charcot-Marie-Tooth disease

The paper identifies monoallelic DHX9 variants as a cause of neurodevelopmental disorders and Charcot-Marie-Tooth disease, showing genotype-phenotype correlations and cellular dysfunction.

A resource of targeted mutant mouse lines for 5,061 genes

The paper reports the generation of over 5,000 new mouse mutant strains for targeted genes, significantly expanding the available genetic resources for biomedical research.

SERF deletion modifies amyloid aggregation in a mouse model of Alzheimer's disease

This study shows that SERF2 deletion changes amyloid fibril structure in Alzheimer's mouse models, suggesting SERF's role in modifying amyloid aggregation.

Human and mouse essentiality screens as a resource for disease gene discovery

The paper integrates gene essentiality data from human and mouse screens to classify genes into FUSIL categories, identifying developmental lethal genes associated with rare diseases.

Soft Windowing Application to Improve Analysis of High-throughput Phenotyping Data

The paper introduces a method called soft windowing to improve analysis of high-throughput phenotyping data by reducing false positives and increasing significant results.