NeuroscienceProceedings of the National Academy of SciencesPeer-reviewed
"Self-inactivating" rabies viruses are susceptible to loss of their intended attenuating modification
Lei Jin, Makoto Matsuyama, Heather A. Sullivan…·Ian R. Wickersham
The paper shows that a modified rabies virus intended for noncytotoxic neuronal tracing lost its modification due to mutations, leading to paradoxical results, and that the modified virus requires exogenous protease for efficient spread.
16 citations