Nicholas E. Lea

This study shows kinase condensates enhance autophosphorylation by concentrating kinases and ATP, revealing phase separation as a mechanism to activate kinase signaling.

The paper shows that a modified rabies virus intended for noncytotoxic neuronal tracing lost its modification due to mutations, leading to paradoxical results, and that the modified virus requires exogenous protease for efficient spread.

This paper introduces third-generation rabies viral vectors with single deletions that enable more efficient, non-toxic retrograde targeting of projection neurons compared to previous generations.

This paper introduces a non-toxic rabies virus system for long-term in vivo imaging of neuronal networks, showing minimal toxicity and normal visual response properties over 10 weeks.

The paper shows that helper virus concentrations significantly affect transsynaptic tracing efficiency and nonspecific labeling in monosynaptic tracing experiments.