Ian R. Wickersham

The paper introduces Seq-o-Matic, an open-source automated in situ sequencer that reduces hands-on time and improves sequencing consistency across tissue sections.

The paper identifies striosomal pathways that target substantia nigra dopamine neurons, with opposite effects on movement compared to canonical pathways.

This study uses barcoded rabies virus with single-cell and in situ sequencing to map synaptic connectivity in the mouse brain, distinguishing cortical cell types by their connectivity patterns.

The paper shows that a modified rabies virus intended for noncytotoxic neuronal tracing lost its modification due to mutations, leading to paradoxical results, and that the modified virus requires exogenous protease for efficient spread.

This study shows that cingulate cortex inputs to motor cortex are necessary for updating rule representations during sequential choice decisions after rule switches.

This paper introduces third-generation rabies viral vectors with single deletions that enable more efficient, non-toxic retrograde targeting of projection neurons compared to previous generations.

This paper introduces a non-toxic rabies virus system for long-term in vivo imaging of neuronal networks, showing minimal toxicity and normal visual response properties over 10 weeks.

The paper maps functional domains and subnetworks in the cortico-basal ganglia-thalamic loop in mice, revealing complex patterns of convergence and divergence.

The paper creates a multiscale connectivity atlas of the mouse BLA by analyzing circuit-tracing data to identify distinct projection neuron domains and their brain-wide targets.

This study identifies distinct roles of prefrontal cortex projections in modulating sensorimotor behavior through separate circuits for motor response coordination and sensory cue processing.

The paper shows that a small number of dysregulated adult-born neurons in the hippocampus disrupt brain-wide functional connectivity and spatial memory.

The paper identifies Chx10-lineage reticulospinal neurons that control left/right locomotor asymmetries in mammals through ipsilateral and contralateral projections.

This study maps cortico-tectal projections in the mouse brain, identifying four collicular zones with distinct cortical inputs and subnetwork organization.

The paper shows that helper virus concentrations significantly affect transsynaptic tracing efficiency and nonspecific labeling in monosynaptic tracing experiments.

The paper identifies shared and distinct transcriptomic cell types in two mouse neocortical regions using scRNA-seq, showing most excitatory types are region-specific while inhibitory types are shared.