Predicted mechanistic impacts of human protein missense variants
Jürgen Jänes, Marc Müller, Senthil Selvaraj, Diogo Manoel, James D. Stephenson, Catarina Inês Gonçalves, Aleix Lafita, Benjamin J. Polacco, Kirsten Obernier, Kaur Alasoo, Manuel Carlos Lemos, Nevan J. Krogan, Maria Jesus Martin, Luís R. Saraiva, David F. Burke, Pedro Beltrão
The paper predicts the mechanistic impacts of human protein missense variants on stability, protein-protein interactions, and small-molecule binding using AlphaFold2 structures.
bioRxiv · May 29, 2024 · PreprintBioinformatics