Aleix Lafita

The paper presents the cryo-EM structure of a β1-adrenoceptor-AmpC β-lactamase fusion protein in the inactive state, revealing conformational dynamics and potential for GPCR structure elucidation.

The paper predicts the mechanistic impacts of human protein missense variants on stability, protein-protein interactions, and small-molecule binding using AlphaFold2 structures.

The paper reports high-resolution cryo-EM structures of human RNA polymerase I, revealing structural features and disease-related mutations.

The paper presents cryo-EM structures of human RNA polymerase III in unbound and transcribing states, revealing structural insights into its function and disease associations.

The paper improves CE-Symm to detect and analyze protein symmetry and repeats, enhancing applications in classification and evolutionary studies.

The paper presents a method to assess the quaternary structure of proteins from crystal data by combining interface classification with symmetry and topology analysis, achieving 85% precision on a new dataset.