Author
European Bioinformatics InstituteORCID 0000-0001-8830-3951Unclaimed ORCID profile · follow to get notified of new preprints
5 papers
Recent·Most cited
Adinda Kok, Samuel H. Wilks, Sina Türeli…·Mathilde Richard
The paper creates a high-resolution antigenic map of A(H5) HA and uses it to design vaccine antigens that confer broad immunity against diverse A(H5) viruses.
Claudia Feng, Elin Madli Peets, Yan Zhou…·Britta Velten
The paper presents a genome-scale CRISPRi perturbation map in human pluripotent stem cells using single-cell RNA sequencing to study trans gene regulation across diverse genetic backgrounds.
Jürgen Jänes, Marc Müller, Senthil Selvaraj…·Pedro Beltrão
The paper predicts the mechanistic impacts of human protein missense variants on stability, protein-protein interactions, and small-molecule binding using AlphaFold2 structures.
Belinda Wang, Rasika S. Vartak, Yefim Zaltsman…·Nevan J. Krogan
The paper constructs a PPI network of 100 high-confidence ASD genes, identifies novel interactions, and uses AlphaFold-Multimer to prioritize variants for functional validation in organoids.
David F. Burke, Patrick Bryant, Inigo Barrio‐Hernandez…·Arne Elofsson
The paper uses AlphaFold2 to predict structures for 65,484 human protein interactions, identifying high confidence models and disease-related mutations.