Development of DARPin T cell engagers for specific targeting of tumor-associated HLA/peptide complexes
Natalia Venetz, Tim Paul Schulte, Sandra Müller, K. Wallden, Stefanie Fischer, Tom Resink, Nadir Kadri, Maria Paladino, Nicole Pina, Filip Radom, Denis Villemagne, Sandra Bruckmaier, Andreas Cornelius, Tanja Hospodarsch, Evren Alici, , Adnane Achour
This study develops DARPin T cell engagers that specifically target HLA/peptide complexes on tumor cells, showing high affinity and specificity through in vitro selection and structural analysis.
iScience · Nov 5, 2025Peer-reviewedSynthetic Biology