Tom Resink

The paper decodes correlated dynamics at the pMHC interface to understand TCR recognition and immunogenicity using computational methods.

This study develops DARPin T cell engagers that specifically target HLA/peptide complexes on tumor cells, showing high affinity and specificity through in vitro selection and structural analysis.

This study characterizes the conformational dynamics of G3BP1 under different pH conditions and shows how its structural changes enable phase separation.