Adnane Achour

Immune repertoire profiling reveals extensive clonal expansion of T and B cells in CXCL9-rich niches in sinonasal cancer

The paper uses spatial and single-cell techniques to show T and B cell clonal expansion in CXCL9-rich niches of sinonasal cancer, linking immune hubs to tumor regions.

Studying macromolecular composition in cell-cell interfaces using 3D membrane reconstitution systems

This paper develops artificial and semi-artificial 3D membrane systems to study protein, lipid, and glycocalyx distribution at cell-cell interfaces, revealing differential partitioning and activation dynamics.

From Structure to Immunogenicity: Decoding Correlated Dynamics atthe Peptide MHC interface to Understand TCR Recognition

The paper decodes correlated dynamics at the pMHC interface to understand TCR recognition and immunogenicity using computational methods.

Design of solubly expressed miniaturized SMART MHCs

This paper designs soluble, miniaturized MHC proteins that enable stable expression in E. coli and retain peptide and TCR binding specificity.

Insight into Malt1 activation mechanism through synergetic approach of AlphaFold, MD Simulation and NMR dynamic analyses

The paper investigates MALT1 activation dynamics using a combination of AlphaFold, MD simulations, and NMR analyses, revealing how ionic strength influences its conformational states.

Development of DARPin T cell engagers for specific targeting of tumor-associated HLA/peptide complexes

This study develops DARPin T cell engagers that specifically target HLA/peptide complexes on tumor cells, showing high affinity and specificity through in vitro selection and structural analysis.

Accurate Protein Dynamic Conformational Ensembles: Combining AlphaFold, MD and Amide 15N(1H) NMR Relaxation.

The paper combines AlphaFold, MD simulations, and NMR relaxation data to identify biologically relevant protein conformational ensembles for a specific bacterial protein.

Mutational insights into human kynurenine aminotransferase 1: modulation of transamination and β-elimination activities across diverse substrates

This study investigates how mutations in hKYAT1 affect its transamination and β-elimination activities across various substrates, identifying key residues that influence enzyme function.

Solution architecture of G3BP1 reveals pH-dependent conformational switching underlying liquid-liquid phase separation

This study characterizes the conformational dynamics of G3BP1 under different pH conditions and shows how its structural changes enable phase separation.

Crystallographic and NMR studies of Streptococcus pneumonia LCP protein PsrSp indicate the importance of dynamics in four long loops for ligand specificity

The paper determines the crystal structure of PsrSp and uses NMR to analyze its dynamics, showing that four long loops contribute to ligand specificity through their mobility.

Towards understanding of allostery in MALT1: a possible role of interdomain motions as revealed by NMR and AlphaFold

The paper investigates the dynamic behavior of MALT1 using NMR and AlphaFold to reveal interdomain motions involved in allosteric regulation.

An alpaca nanobody neutralizes SARS-CoV-2 by blocking receptor interaction

This paper identifies an alpaca nanobody that neutralizes SARS-CoV-2 by blocking the ACE2 receptor interaction.