Targeting the COP9 signalosome overcomes platinum resistance in ovarian cancer through two distinct genome stability mechanisms
Elena Lomonosova, Megan Loeb, Kevin Rodriguez, Lilian N. van Biljon, Joshua D. Brill, Angela M. Schab, Margaret Minett, Jaeden Barron, Maya Bittner, Jiyoung Park, Rebecca Drexler, Carmen Sandoval, Alyssa Oplt, Eden Gallup, Prasanth Thuthika, , Mary Margaret Mullen
The paper identifies COPS5 as a therapeutic target for overcoming platinum resistance in ovarian cancer by inhibiting nucleotide excision repair and interstrand crosslink repair.
bioRxiv · Aug 4, 2025 · PreprintCancer Biology