Tunable Bias Signaling of the Angiotensin II Type 1 Receptor for Inotropy via C-Terminal Peptide Modifications and Allosteric Site Targeting
Margot Hadjadj, Justin Martel, Marie-Frédérique Roy, Malihe Hassanzadeh, Hugo Giguère, Alexandre Murza, Brian J. Holleran, Yoon Namkung, Ulrike Froehlich, Richard Leduc, Mannix Auger‐Messier, Stéphane A. Laporte, Pierre‐Luc Boudreault
This study identifies AngII analogs with modified C-terminal peptides that selectively engage Gq or β-arrestin pathways, showing differential effects on cardiac function and blood pressure in rats.
bioRxiv · Aug 13, 2025 · PreprintMolecular Biology