Yoon Namkung

Allosteric pathways govern Gα protein coupling selectivity at promiscuous GPCRs

The paper identifies allosteric pathways that determine G protein coupling selectivity in promiscuous GPCRs using a combination of mutagenesis, simulations, and machine learning.

Interpretable Machine Learning Model of Receptor Dynamics Reveals AT1R Allostery and a Negative Allosteric Modulator

The paper develops an interpretable machine learning model to identify allosteric modulators of the AT1R receptor and discovers a negative allosteric modulator.

Tunable Bias Signaling of the Angiotensin II Type 1 Receptor for Inotropy via C-Terminal Peptide Modifications and Allosteric Site Targeting

This study identifies AngII analogs with modified C-terminal peptides that selectively engage Gq or β-arrestin pathways, showing differential effects on cardiac function and blood pressure in rats.

Development of a genetically encoded melanocortin sensor for high sensitivity intravital imaging

This paper develops a genetically encoded melanocortin sensor, FLAREMC, for high sensitivity intravital imaging of melanocortin signaling in vivo.