UBA1 Mutations Drive RIPK1-Mediated Cell Death and Monocyte Dysfunction in VEXAS Syndrome
Paul Breillat, Samuel J. Magaziner, Stéphane M. Camus, Léa Dionet, Benjamin De Valence, Pierre Sohier, Amine Majdi, Quentin Delcros, Federica Pallotti, Nadia Rivet, Kevin Chevalier, Margot Poux, Pierre‐Louis Tharaux, Olivia Lenoir, Abdelrahim Zoued, , Benjamin Terrier
This study investigates how UBA1 mutations in VEXAS syndrome lead to monocyte dysfunction and inflammation through RIPK1-mediated cell death and impaired NF-κB signaling.
bioRxiv · Oct 6, 2025 · PreprintImmunology