Pierre‐Louis Tharaux

This study develops a mouse model of hypertensive emergency with multiorgan microvascular disease and identifies dysregulated VEGFA/sFlt-1 signaling as a key driver.

This study identifies polyploid cardiomyocytes as disease-specific transcriptional states in the mammalian heart and suggests targeting them for heart failure treatment.

This study investigates how UBA1 mutations in VEXAS syndrome lead to monocyte dysfunction and inflammation through RIPK1-mediated cell death and impaired NF-κB signaling.

This study shows that blood-borne sphingosine 1-phosphate (S1P) maintains vascular resistance and cardiac function through albumin-S1P and myocyte S1PR signaling in mice.