Author

Samuel J. Magaziner

New York UniversityORCID 0000-0002-5345-217XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Assay:metabolomics· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

David B. BeckiD· 2 shared Abdelrahim ZouediD· 1 shared Achim A WerneriD· 1 shared Amine MajdiiD· 1 shared Amy K. WangiD· 1 shared Benjamin De ValenceiD· 1 shared Benjamin TerrieriD· 1 shared Brecca MilleriD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersGenetics

David B. BeckORCID

Mutual co-authors in cluster

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2 papers

Recent·Most cited

Cell autonomous inflammation in VEXAS is mediated by cGAS-STING

Samuel J. Magaziner, Jason C. Collins, Brecca Miller, Patrick Zheng, Amy K. Wang, Jérôme Hadjadj, Juan Carlos Balandrán, Maria Sirenko, Maya English, James Bertlin, Rebecca L. Murray, Peter H. Whitney, Tania J González-Robles, Deborah Rivera, Yan Wang, , David B. Beck

This study identifies cGAS-STING pathway activation as a key mechanism of inflammation in VEXAS, showing that UBA1 mutations disrupt ERAD and mitochondrial homeostasis, leading to STING-driven inflammation.

bioRxiv · May 29, 2026 · PreprintGenetics

UBA1 Mutations Drive RIPK1-Mediated Cell Death and Monocyte Dysfunction in VEXAS Syndrome

Paul Breillat, Samuel J. Magaziner, Stéphane M. Camus, Léa Dionet, Benjamin De Valence, Pierre Sohier, Amine Majdi, Quentin Delcros, Federica Pallotti, Nadia Rivet, Kevin Chevalier, Margot Poux, Pierre‐Louis Tharaux, Olivia Lenoir, Abdelrahim Zoued, , Benjamin Terrier

This study investigates how UBA1 mutations in VEXAS syndrome lead to monocyte dysfunction and inflammation through RIPK1-mediated cell death and impaired NF-κB signaling.

bioRxiv · Oct 6, 2025 · PreprintImmunology