Insulin-binding B cells can arise in early-stage type 1 diabetes individuals in the absence of somatic hypermutation or insulin autoantibody seropositivity
Lindsay E Bass, Tommi C Taylor, Mason V Forchetti, Steven Scaglione, Marguerite L Padgett, Alaina M Skellett, Cooper W Byers, Anika Mahajan, Christina T Brannon, Perry T. Wasdin, Sabina E W Leonard, Ivelin S. Georgiev, Daniel J. Moore, Scott Alan Smith, Rachel H. Bonami
The paper identifies anti-insulin B cells in early-stage T1D patients without autoantibodies or somatic hypermutation, showing their role in autoimmunity.
bioRxiv · Oct 22, 2026 · PreprintImmunology